I'm currently reading Looking For Alaska by John Green http://www.amazon.com/Looking-Alaska-Paperback-Green-John/dp/B00144R62Q/ref=sr_1_3?ie=UTF8&s=books&qid=1273553488&sr=8-3 and it, like his other FANTASTIC books, is about a geeky high schooler. He's taking a World Religions course and the fossil of a teacher assigns the class to write its final paper on what the post important question is.
Up until reading Lamb by Christopher Moore http://www.amazon.com/Lamb-Gospel-According-Christs-Childhood/dp/0380813815/ref=sr_1_1?ie=UTF8&s=books&qid=1273553596&sr=1-1 I dunno what I would have considered to be the most important question.
Growing up super-Catholic, "The Word of God," "The Word made flesh" and other references to "The Word" were frequently said in mass, class, prayer, educational films, etc. I understood nothing in kindergarten, "The Word" didn't stand out. I paid little attention as I grew up since thinking about things over which you have no authority is sinful. When I finally rebelled, I didn't think about anything except for emptying my head of that brainwashing. Years later, when I returned to the pile of brain-guck I had scooped out, I didn't understand "The Word" any more than as a child.
In Lamb, Jesus is told that what the Hebrew people needed was the Word of God. They were poor, struggling, had no control over their own lives, and their political activists were getting publicly slain. Moses, Elijah and other prophets had heard and delivered the Word of God in bad times before. Jesus needed to BE the Word for them now. He needed to be the manifestation of the Word of God in order to lead them.
In this way, human beings ARE our most important question. We are the question of time, will, adaptation, creativity, destruction, society, etc. manifest and we are also the answer.
Sometimes I miss school (certain classes) because you don't often encounter questions like these with the will to answer them otherwise...except for blog geeks like me. Thanks, John and Christopher!